Researchers
Helen (Qi-Cong) Zhu, Ph.D.
Professional Specialist, Department of Chemistry and Biochemistry
Contact Information
- Office: 370 Stepan Chemistry Hall
- Email: hzhu@nd.edu
- Phone: (574) 631-5607
Biography
Dr. Zhu received her B.S. degree in chemistry from Langzhou University, People's Republic of China. She earned her M.S. degree in 1988 and her Ph.D. in 1992, both in chemistry from Drexel University. Subsequently, she conducted postdoctoral research from 1992 to 1994 at Purdue University, where she designed, synthesized, and evaluated new anti-cancer agents. From 1997 to 2002, Dr. Zhu worked as scientist at Abbott Laboratories conducting process research on ketolide antibiotics, the HIV protease inhibitor ritonavir, the cardioselective agent betaxosol, and treatments for gout and hyperuricemia. She joined the faculty of the University of Notre Dame in 2002.
Research Interests
Dr. Zhu's interests are in synthetic chemistry. Her research focuses on the design, synthesis, and evaluation of analogs of amamistatin and mycobactin as potential anti-cancer agents. She is also investigating structure-activity relationships of this novel class of anti-cancer agents by parallel synthesis.
Publications
Miller MJ, Hu J, Xu Y, Walz AJ, Zhu H, Fennell K, Bodnar, Sheinkman BA, Moraski G. Design, syntheses and studies of mycobacterial siderophores with selective antiTB activity. Keystone Symposia, Tuberculosis (D1), Canada, April, 2005.
Robbins TA, Zhu H, Shao J. Process for preparing substituted thiazoles. U.S.Pat. Appl. Publ. 2005, 6 pp. CODEN: USXXCO US 2005027128 A1 20050203.
Hutchins RO, Zhu QC, Adams J, Oskay E, Abdel-Magid A, Hutchins MK. Diastereo- and enantioselective hydride reductions of ketone phosphinyl imines to phosphinyl amines: Synthesis of protected amines and amino acids. In Reductions in Organic Synthesis, ACS Symp Ser 1996; 641: 127-137.
Zhu QC, Hutchins RO, Hutchins MK. Asymmetric reductions of carbon-nitrogen double bonds: A review. Org Prep Proced Int 1994; 26: 193-236.
Cushman M, Zhu H, Geahlen RL, Kraker AJ. Synthesis and biochemical evaluation of a series of aminoflavones as potential inhibitors of protein-tyrosine kinase p56lck, EGFr, and p60v-src. J Med Chem 1994; 37: 3353-3362. link
