Researchers

Bradley D. Smith, Ph.D.

Bradley D. Smith, Ph.D.

Professor, Department of Chemistry and Biochemistry

Contact Information

Biography

Professor Smith earned his B.Sc. degree in 1983 from the University of Melbourne and his Ph.D. in 1988 from the Pennsylvania State University.  He conducted postdoctoral research at Oxford University and then at Columbia University as a Merck postdoctoral fellow. He joined the faculty at the University of Notre Dame in 1991. Professor Smith was the Research Corporation Cottrell Scholar from 1994 to 1999 and the recipient of the University of Notre Dame Kaneb Outstanding Undergraduate Teaching Award and NSF Early Career Development Award.

Research Interests

Professor Smith's research interests cover topics in supramolecular and bioorganic chemistry.  His research program focuses on the design and synthesis of organic molecules that affect the dynamics of phospholipid bilayer membranes.  Specifically his group is interested in controlling (activating or inhibiting) the biologically and pharmaceutically important processes of chloride transport, membrane receptor dimerization, phospholipid flip-flop, and pore formation.  Professor Smith's research group is also designing sensors and imaging agents for apoptotic cells.

Publications

Hanshaw RG, O’Neil EJ, Foley M, Carpenter RT, Smith BD. Indicator displacement assays that detect bilayer membranes enriched in phosphatidylserine. J Materials Chem 2005; 15: 2707-2713. link

Jiang H, O’Neil EJ, DiVittorio KM, Smith BD. Anion-mediated phase transfer of Zinc(II)-coordinated tyrosine derivatives. Org Lett 2005; 7: 3013-3016. link

DiVittorio KM, Lambert TN, Smith BD. Steroid-derived phospholipid scramblases induce exposure of phosphatidylserine on the surface of red blood cells. Bioorg Med Chem 2005;13: 4485-4490. link

Gale PA, Light ME, McNally B, Navakhun K, Sliwinski KE, Smith BD. Co-transport of H+/Cl- by a Synthetic Prodigiosin Mimic. Chem Comm 2005; 30: 3773-3775. link

Hanshaw RG, Smith BD. New reagents for phosphatidylserine recognition and detection of apoptosis. Bioorg Med Chem 2005; 13: 5035-5042. link

Cells