Researchers
Shahriar Mobashery, Ph.D.
Navari Family Professor in Life Sciences, Department of Chemistry and Biochemistry
Contact Information
- Office: 423 Nieuwland Science Hall
- Email: mobashery@nd.edu
- Phone: (574) 631-2933
- Visit Website
Biography
Professor Mobashery obtained his B.S. degrees in biological sciences and chemistry in 1980 and 1981, respectively, from the University of Southern California. He received his Ph.D. in chemistry in 1985 from the University of Chicago. Subsequently, he conducted postdoctoral research at Rockefeller University from 1986 to 1988 as a National Institutes of Health postdoctoral fellow. He joined the faculty at Wayne State University in 1989, becoming professor in 1997 and director of the Institute for Drug Design in 2000. Professor Mobashery moved to the University of Notre Dame in 2003 as the Navari Family Professor in Life Sciences. He was the Charles H. Gershenson Distinguished Faculty Fellow and the recipient of the Award of the Society of Synthetic Organic Chemistry-Japan, the Wayne State University Career Development Chair Award, and the Wayne State University Award of Excellence in Teaching. Professor Mobashery serves on various governmental and industrial panels and on the editorial board of eight scientific journals.
Research Interests
Professor Mobashery's research interests center on bioorganic chemistry, organic synthesis, protein chemistry, enzymology, and computational sciences. His research group employs a multidisciplinary approach to solve problems at the interface of chemistry and biology, areas that encompass studies of the mechanisms of resistance to antibiotics and the means to circumvent them, development of novel antibiotics and their mechanism of action, and investigations of complex microbial systems such as the outer membrane and the cell wall. In addition, Professor Mobashery's group is interested in the molecular mechanism of cancer metastasis and its intervention by rational design of molecules that interfere with the growth and spread of tumors.
Publications
Lee M, Bernardo MM, Meroueh SO, Brows S, Fridman R, Mobashery S. Synthesis of Chiral 2-(4-Phenoxyphenylsulfonylmethyl)-thiiranes as Selective Gelatinase Inhibitors. Org. Lett. 2005, 7, 4463-4465. link
Ikejiri M, Bernardo MM, Bonfil RD, Toth M, Chang M, Fridman R, Mobashery S. Potent Mechanism-Based Inhibitors for Matrix Metalloproteinases, J. Biol. Chem. 2005, 280, 33992-34002. link
Bonfil RD, Sabbota A, Nabha S, Bernardo MM, Dong Z, Meng H, Yamamoto H, Chinni SR, Lim IT, Chang M, Filetti LC, Mobashery S, Cher ML, Fridman R. Inhibition of Human Prostate Cancer Growth, Osteolysis and Angiogenesis in a Bone Metastasis Model by a Novel Mechanism-Based Selective Gelatinase Inhibitor, Int. J. Cancer 2006, 118, 2721-2726. link
Fisher JF, Mobashery S. Recent Advances in MMP Inhibitor Design, Cancer Metastasis Rev., 2006, 25, 115-136. link
Hesek D, Noll BC, Mobashery S. Side Reaction of Significance in Preparation of Peptide- or Peptidomimetic-Based Hydroxamate Enzyme Inhibitors, J. Org. Chem. 2006, 71, 2885-2887. link
Hesek D, Toth M, Meroueh SO, Brown S, Zhao H, Sakr W, Fridman R, Mobashery S. Design and Characterization of a Metalloproteinase Inhibitor-Tethered Resin for the Detection of Active MMPs in Biological Samples, Chemistry & Biology 2006, 13, 379-386. link
Hesek D, Toth M, Krchnak V, Fridman R, Mobashery S. Synthesis of an Inhibitor-Tethered Resin for Detection of Active Matrix Metalloproteinases Involved in Disease, J. Org. Chem. 2006, 71, 5848-5854. link
