Researchers

Marvin J. Miller, Ph.D.

Marvin J. Miller, Ph.D.

George and Winifred Clark Professor

Contact Information

Biography

Professor Miller received his B.S. degree in chemistry in 1971 from North Dakota State University. He earned his Ph.D. in 1976 in chemistry from Cornell University. He conducted postdoctoral research from 1975 to 1977 at the University of California at Berkeley as a National Institutes of Health fellow. He joined the faculty of the University of Notre Dame in 1977. Professor Miller was an Alfred P. Sloan fellow from 1981 to 1885 and was the recipient of an NIH Research Career Development Award, the University of Notre Dame Schilts/Leonard and Kaneb Teaching Awards, and the University Presidential Award. He has served on various governmental and industrial panels, and on the editorial boards of several scientific journals. He consults for several major pharmaceutical companies and biotechnology companies. Professor Miller is the author of 206 refereed publications, a major textbook and 18 patents.

Research Interests

Professor Miller's interests are in synthetic and bioorganic chemistry. His research focuses on the development of new methodology and its incorporation into the synthesis and study of biologically important nitrogen containing compounds with special emphasis on the hydroxamic acid containing microbial iron transport agents, amino acids, peptides, carbocylic nucleosides, ß-lactam antibiotics, antifungal, and antitumor agents.

Publications

Moody DB, Yung DC, Cheng TY, Rosat JP, Roura-mir C, O’Connor PB, Zajonc DM, Walz A, Miller MJ, Levery SB, Wilson IA. Costello CE, Brenner MB. T cell activation by lipopeptide antigens. Science 2004; 303: 527-531. link

Dong L, Miller MJ, Möllmann U. Microbial growth promotion studies of exochelin MN and analogues thereof. BioMetals 2004; 17: 99-104. link

Li F, Brogan JB, Gage JL, Zhang D, Miller MJ. Chemoenzymatic synthesis and synthetic application of enantiopure aminocyclopentenols: total synthesis of carbocyclic (+)-uracil polyoxin C and its alpha-epimer. J Org Chem 2004; 69: 4538-4540. link

Ding P, Miller MJ, Chen Y, Helquist P, Oliver AJ, Wiest O. Syntheses of conformationally constricted molecules as potential NAALADase/PSMA inhibitors. Org Lett 2004; 6: 1805-1808. link

Lee W, Miller MJ. Concise synthesis of 4-acylamino analogues of 2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acids (LY354740) from an acylnitroso Diels-Alder cycloadduct. J Org Chem 2004; 69: 4516-4519. link

Girijavallabhan V, Miller MJ. Therapeutic uses of Iron(III) chelators and their antimicrobial conjugates. In Iron Transport in Bacteria, Crosa JH, Mey AR, Payne SM, eds., Chapter 27, 2004, 413-433.

Li F, Warshakoon NC, Miller MJ. Synthetic application of acylnitroso Diels-Alder derived-aminocyclopentenols: total synthesis of (+)-streptazolin. JOrg Chem 2004; 69: 8836-8841. link

Bernier G, Girijavallabhan V, Murray A, Niyaz N, Ding P, Miller MJ, Malouin F. Desketoneoenactin-siderophore conjugates for Candida: evidence of iron transport-dependent species selectivity. J Antimicrobial Agents Chemother 2004; 49: 241-248.

Jiang M, Warshakoon NC, Miller MJ. Chemoenzymatic asymmetric total synthesis of phosphodiesterase inhibitors: preparation of a polycyclic pyrazolo[3,4-d]pyrimidine from an acylnitroso Diels-Alder cycloadduct-derived amino cyclopentenol. J Org Chem 2005; 70: 2824-2827. link

Zajonc DM, Crispin MDM, Bowden TA, Young DC, Cheng TY, Hu J, Costello CE, Rudd PM, Dwek RA, Miller MJ, Brenner MB, Moody DB, Wilson IA. Molecular mechanism of lipopeptide presentation by CD1a. Immunity 2005; 22: 209-219. link

Cells