Researchers
Victoria A. Ploplis, Ph.D.
Research Professor, Department of Chemistry and Biochemistry
Associate Director, W.M. Keck Center for Transgene Research
Contact Information
- Office: 440 Stepan Chemistry Hall
- Email: ploplis.3@nd.edu
- Phone: (574) 631-4017
- Visit Website
Biography
Dr. Ploplis received her B.A. degree in biology/chemistry in 1975 from Rosary College and her Ph.D. in biochemistry in 1981 from the University of Notre Dame. She conducted postdoctoral research at the University of Notre Dame, then at Scripps Research Institute from 1982 to 1984. Subsequently, Dr. Ploplis was senior scientist and director of cardiovascular research at American Biogenetic Sciences, Inc. (1984-1994), and assistant staff at the Cleveland Clinic Research Foundation (1994-1998). She joined the faculty of the University of Notre Dame in 1998. Dr. Ploplis was the recipient of the American Heart Association John Hickam postdoctoral fellowship and the National Institutes of Health James A. Shannon Award. She is currently an elected fellow on the American Heart Association Council on Atherosclerosis, Thrombosis, and Vascular Biology.
Research Interests
Dr. Ploplis' research efforts focus on defining the in vivo roles of genes encoding hemostatic proteins in a variety of functions that include hemostasis, inflammation, and cancer.
Publications
Gutierrez LS, Suckow M, Lawler J, Ploplis VA, Castellino FJ. Thrombospondin 1-a regulator of adenoma growth and carcinoma progression in the APCMin/+ mouse model. Carcinogenesis 2003; 24: 199-207. link
Sato J, Schorey J, Ploplis VA, Haalboom E, Krahule L, Castellino FJ. The fibrinolytic system in dissemination and matrix protein deposition during a mycobacterium infection. Am J Pathol 2003; 163: 517-531.
Ploplis VA, Castellino FJ. Gene targeting of components of the fibrinolytic system. Thromb Haemost 2002; 87: 22-31.
Iwaki T, Sandoval-Cooper MJ, Paiva M, Kobayashi T, Ploplis VA, Castellino FJ. Fibrinogen stabilizes placental-maternal attachment during embryonic development in the mouse. Am J Pathol 2002; 160: 1021-1034.
Zeng B, Bruce D, Kril J, Ploplis V, Freedman B, Brieger D. Influence of plasminogen deficiency on the contribution of polymorphonuclear leucocytes to fibrin/ogenolysis: studies in plasminogen knock-out mice. Thromb Haemost 2002; 88: 805-810.
