Researchers

Francis J. Castellino, Ph.D.

Francis J. Castellino, Ph.D.

Kleiderer/Pezold Professor, Department of Chemistry and Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science

Contact Information

Biography

Professor Castellino obtained his B.S. degree in chemistry in 1964 from the University of Scranton. He earned his M.S. degree in 1966 and his Ph.D. in biochemistry in 1968, both from the University of Iowa. He conducted postdoctoral research at Duke University from 1968 to 1970 as a National Institutes of Health postdoctoral fellow. He joined the faculty at the University of Notre Dame in 1970. Professor Castellino was the recipient of the Camille and Henry Dreyfus Teacher Scholar Award, the NIH Research Career Development Award, the NIH MERIT Award, and Educator of the Year Award. He is an elected fellow of the New York Academy of Sciences, the American Association for Advancement of Science, and the American Heart Association. Professor Castellino is a member of the editorial boards of the Journal of Biological Chemistry, Biotechnology and Applied Biochemistry, and Frontiers in Biosciences, and is the editor-in-chief of Current Drug Targets. He is the founding director of the Center for Transgene Research and the Walther Cancer Research Center at Notre Dame.

Research Interests

Professor Castellino's research interests focus on the structure, function, and activation of the proteins involved in blood coagulation, anticoagulation, and fibrinolysis, and in vivo crosstalk between coagulation- and inflammation-based genes. His research group is also interested in cell-specific glycosylation of proteins, and brain NMDA receptor agonists and antagonists.

Publications

Ganopolsky JG, Castellino FJ. A protein C deficiency exacerbates inflammatory and hypotensive responses in mice during polymicrobial sepsis in a cecal ligation and puncture model. Am J Pathol 2004; 165: 1433-1446.

Yang R, Prorok M, Castellino FJ, Weliky DP. A trimeric HIV-1 fusion peptide construct which does not self-associate in aqueous solution and which has 15-fold higher membrane fusion rate. J Am Chem Soc 2004; 126: 14722-14723. link

Dai Q, Prorok M, Castellino FJ. A new mechanism for metal ion-assisted interchain helix assembly in a naturally-occurring peptide mediated by optimally spaced gamma-carboxyglutamic acid residues. J Mol Biol 2004; 336: 731-744. link

Iwaki T, Cruz DT, Martin JA, Castellino FJ. A cardioprotective role for the endothelial protein C receptor in lipopolysaccharide-induced endotoxemia in the mouse. Blood 2005; 105: 2364-2371. link

Lay AJ, Liang Z, Rosen ED, Castellino FJ . Mice with a severe deficiency in protein C display prothrombotic and proinflammatory phenotypes and compromised maternal reproductive capabilities. J Clin Invest 2005; 115: 1552-1556. link