Researchers
Crislyn D'Souza-Schorey, Ph.D.
Walther Associate Professor, Department of Biological Sciences
Contact Information
- Office: 145 Galvin Life Science Center
- Email: cdsouzas@nd.edu
- Phone: (574) 631-3735
- Visit Website
Biography
Professor D'Souza-Schorey received her Ph.D. degree in biochemistry from the University of Texas Health Science Center at San Antonio in 1992. She was a postdoctoral research fellow (1993-96) and research assistant professor (1997-98) in the Department of Cell Biology at Washington University School of Medicine in St. Louis. She joined the faculty of the University of Notre Dame in 1998. Professor D'Souza-Schorey has been the recipient of several awards and honors during her career, which include the Welch predoctoral fellowship, the Lucille P. Markey postdoctotral fellowship in pathobiology, the Leukemia and Lymphoma Society of America Special Fellowship and junior faculty awards from the American Cancer Society and the Leukemia Research Foundation. She holds the Walther Cancer Institute Endowed Junior Chair since 1998.
Research Interests
Professor D'Souza-Schorey's research interests focus on GTPase-mediated regulation of endosomal membrane transport and actin cytoskeletal remodeling. Her research group is particularly interested in investigating the roles of the aforementioned processes in the adhesive and migratory potential of normal and tumor cells, in cell-cycle progression, and in protein aggregation in neurodegenerative disease states.
Publications
D’Souza-Schorey C. Disassembling adherens junctions: Breaking up is hard to do. Trends Cell Biol 2005; 15: 19-26. link
Palacios F, Tushir JS, Fujita Y, D’Souza-Schorey C. Lysosomal targeting of E-cadherin: A unique mechanism for the down-regulation of cell-cell adhesion during epithelial to mesenchymal transitions. Mol Cell Biol 2005; 25: 389-402. link
Tague S, Muralidharan V, D’Souza-Schorey C. ADP-ribosylation factor 6 regulates tumor cell invasion through the activation of the MEK/ERK signaling pathway. Proc Natl Acad Sci USA 2004; 101: 9671-9676. link
Palacios F, D’Souza-Schorey C. Modulation of Rac 1 and ARF6 activation during epithelial cell scattering. J Biol Chem 2003; 278: 17395-17400. link
Muchowski P, Ning K, D’Souza-Schorey C, Fields S. Requirement of an intact microtubule cytoskeleton for aggregation and inclusion body formation by a mutant huntingtin fragment. Pro Natl Acad Sci USA 2002; 99: 727-732. link
Peters PJ, Ning K, Palacios F, Boshans RL, Kazantsez A, Thompson L, Woodman B, Bates GP, D’Souza-Schorey C. Arfaptin 2 regulates the aggregation of mutant huntingtin protein. Nat Cell Biol 2002; 4: 240-245.
Schwetizer JK, D’Souza-Schorey C. Localization and activation of the ARF6 GTPase during cleavage furrow ingression and cytokinesis. J Biol Chem 2002; 277: 27210-27216. link
Palacios F, Schweitzer JK, Boshans RL, D’Souza-Schorey C. ARF6-GTP recruits Nm23-H1 to facilitate dynamin-mediated endocytosis during adherens junctions disassembly. Nat Cell Biol 2002; 4: 929-936.
